USS S-5 was an S-class submarine laid down on December 4, 1917 and launched on November 10, 1919. It was commissioned on March 6, the same year under Lt. Cmdr. Charles M. Cooke’s command with the hull number SS-110 and it served in the US Navy for several months before it was sunk by accident on September 1, 1920. During its activities, the ship carried a complement of 38 people on board and had the main missions in Boston, New England, Cape May or Haiti. After the sinking, the ship was struck from the Navy Register in 1921.